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Bis(chloromethyl) ether : ウィキペディア英語版
Bis(chloromethyl) ether

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Bis(chloromethyl) ether is an organic compound with the chemical formula (CH2Cl)2O. It is a colourless liquid with an unpleasant suffocating odour and it is one of the chloroalkyl ethers. Bis(chloromethyl) ether was once produced on a large scale, but was found to be highly carcinogenic and thus such production has all but ceased.
==Synthesis==
It was produced industrially from paraformaldehyde and a mixture of chlorosulfonic acid and sulfuric acid.〔Wilhelm Heitmann, Günther Strehlke, Dieter Mayer “Ethers, Aliphatic” ''Ullmann's Encyclopedia of Industrial Chemistry'' 2002, Wiley-VCH, Weinheim. 〕 It is also produced as a by-product in the Blanc chloromethylation reaction and is a known impurity in technical grade chloromethyl methyl ether.
Because of their carcinogenic potency, the industrial production of chloromethyl ethers ended in most countries in the early 1980s. Bis(chloromethyl) ether was no exception to this with production in the U.S.A. ending in 1982.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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